Tau Therapeutics(美国)

Tau Therapeutics

美国TauTherapeuticswww.tautherapeutics.com研发的T型钙通道阻滞剂米贝拉地尔（mibefradil）用于实体肿瘤的治疗。TauTherapeuticsisdevelopingoncologydrugsforsolidtumorsthatselectivelyinhibittheT-typecalciumchannel.Thecompany’sappr oach,calledInterlacedTherapy™,capitalizesonthecentralroleofcalciuminfluxthroughT-typecalciumchannelsduringcancercellgrowth.T-typecalciumchannelblockadewithTau’sdrugsarreststumorcellsattheirmostvulnerablemetabolicpointinthecellcycle,uniquelyamplifyingtheeffectsofconventionaltherapiesandovercomingdrugresistance.Tau’sfirstproduct,mibefradil,hasbeenusedextensivelyinhumansanditssafetyprofileiswellknown.MibefradilisnowenteringclinicaltrialsforbraincancerwithsupportfromtheNCI.TauTherapeuticsisaprivatecompanybasedinCharlottesville,VA.