Regulus(美国)

Regulus Therapeutics

美国RegulusTherapeuticswww.regulusrx.comRegulus公司始建于2007年是由Alnylam与Isis两家制药公司联合创建的。心血管/代谢性疾病项目中拟用于治疗动脉粥样硬化的靶位microRNA-33。RegulusisfocusedonthediscoveryanddevelopmentofmicroRNAtherapeutics.microRNAsareme mbersofalargeclassofnon-codingRNAsofapproximately22nucleotidesinlengththatregulatemostgenesinthegenome.AsinglemicroRNAcantargetandregulateuptohundredsofgenes,andthesegenesareinvolvedinbiologicalnetworksorpathways.DysregulatedmicroRNAexpressionisinvolvedintheinitiationofmanycomplexmulti-factoraldiseases,includingcancer,inflammatorydisease,fibrosis,andmetabolicdis