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Seragon Pharmaceuticals
SeragonPharmaceuticalswww.seragonpharm.comSeragonPharmaceuticals前身是Aragon的乳癌药物开发部门SeragonPharmaceuticals’orallyactiveselectiveestrogenreceptordegraders(SERDs)representapotentialnewtreatmentforpr ogressivemetastaticbreastcancerthatmaycircumventtheproblemofresistancetoanti-hormonaltherapies.SERDsareestrogenreceptorantagoniststhatalsoinduceaconformationalchangethatresultsinthedegradationofthereceptor.SeragonhasidentifiedmultipleSERDsthathavepharmacokineticprofilessufficienttodrivearobusttherapeuticresponseandresultindegradationofthereceptorandanti-tumoractivity.Thenovelprofileofthesepotent,orallybioavailable,nonsteroidalagentsmayresultingreaterefficacyandresponseratesinpatientswithhormone-refractorybreastcancercomparedtootherdrugsindevelopment.Seragon’smostadvancedleadsinducetumorregressionsinbothtamoxifensensitiveandtamoxifenresi
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