Karyopharm(美国)

Karyopharm Therapeutics

KaryopharmTherapeuticswww.karyopharm.comKaryopharmTherapeutic是一家美国抗癌药物研发公司Foundedin2008,KaryopharmTherapeuticsisaclinical-stagepharmaceuticalcompanyfocusedondiscoveryanddevelopmentofnoveldrugsforthetr eatmentofcancer,inflammationandotherdiseasesrelatedtocellproliferation.Ourleadproductsarefirstinclass,oralSelectiveInhibitorsofNuclearExport(SINE),whichirreversiblyblocknuclear-cytoplasmictransportmediatedbyExportin-1(XPO1,alsocalledCRM1).XPO1istheonlyexporterofthetumorsuppressorproteinsp53,p21,FOXO,pRB,BRACA1,andPP2A,aswellastheanti-inflammatoryproteinIkB,theinhibitorofNFκB.XPO1overexpressionleadstothetransportoftumorsuppressorproteins(TSPs)outofthenucleusandintothecytoplasmwheretheyareunabletofunction.ElevatedlevelsofXPO1correlatewithpoorprognosisinovarian,cervical,pancreatic,andlivercancers,acutemyeloidleukemia